Rare Obesity and Metabolic Disorders

Severe obesity starting early in life is a hallmark of rare genetic disorders of obesity. A hereditary conclusion can ease sentiments of blame or fault and reduce social disgrace for adolescents with these issues and their families. Obesity is a complex and multifactorial disease involving interactions between behavioral, environmental, genetic and metabolic factors that contribute to increased risk for comorbidities and mortality. Severe obesity, defined as BMI at or above 120% of the sex-specific 95th percentile in children and adolescents or BMI at least 40 kg/m2 in adults, affects about 6% and 8% of youths and adults in the United States, respectively. Separating uncommon hereditary problems of corpulence, including BBS and Alström condition from nongenetic weight is basic for understanding heftiness pathogenesis and the headway of focused treatments for people with uncommon hereditary issues of stoutness.

Related Associations of Rare Diseases Research:

Alzheimer's disease Organizations, Ann & Robert H. Lurie Children’s Hospital, Birmingham children’s Hospital, Boston Children’s Hospital, Canadian Organization for Rare Diseases, Chicago Rare Disease Foundation, Children’s hospital of Pittsburgh, National Alliances for Rare Diseases, National Institute of Health (NIH), National Organization for Rare Diseases, NDC Medicine, Rare Diseases Patient Association Funding, Rare Diseases South Africa, Rare Diseases Translational Research Collaboration.



 


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